Journal: Current Opinion in Gastroenterology
Issue: January 2008; 24(1):11-6. PMID: 18043226
Article: Alterations in intestinal microbial flora and human disease
The January 2008 article in a prominent medical journal focuses on the role of "gut flora in human disease." Below, I've attempted to summarize/describe parts of the article relating to inflammatory bowel disease (IBD) and irritable bowel syndrome (IBS):
The article starts off with an introduction which reads:
The summary of the article reads: We focus on the example of an abnormal expansion of gut microbial flora into the small bowel or small intestinal bacterial overgrowth and discuss the effects of bacterial overgrowth on the human host in acute pancreatitis, bacterial gastroenteritis, irritable bowel syndrome, inflammatory bowel disease, hepatic encephalopathy, and fibromyalgia and burn injury. The identification of the underlying role of altered commensal gut microbiota in these and other human diseases could lead to novel diagnostic and therapeutic strategies that would improve clinical outcome.